2020

GT Gain Therapeutics SA

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SITE-DIRECTED ENZYME ENHANCEMENT THERAPY (SEE-Tx) PLATFORM

SEE-Tx is a highly specific, fast and cost-effective drug discovery tool. Using the three-dimensional structure of proteins and proprietary computational technology, the SEE-Tx platform identifies and exploits previously uncharacterised binding sites that are druggable but do not bind the natural substrate.
 

By focusing on non-conventional binding sites, Gain Therapeutics has identified ad hoc structurally targeted allosteric regulators which are able to stabilize misfolding mutations, restore targeted protein’s enzymatic activity and reduce accumulation of toxic substrates.