About Us

Offer Description

We are seeking a computational chemist with solid background on molecular simulations eager to pursue/consolidate a career in structure-based drug discovery. The work involves target assessment (druggability analysis), hit identification (virtual screening), stablishing structure-activity relationships and supporting a multidisciplinary team in the identification of clinical candidates.

The ideal candidate holds a PhD, optionally with 2-3 years of post-doc experience, has a solid theoretical understanding of molecular recognition (protein-ligand association, protein folding), demonstrated experience in the use of molecular dynamics and is skilled in programming/scripting tools that ensure reproducibility and efficiency. Advanced analytical and critical problem-solving skills are essential.

The ability to deal with multiple tasks and deliver results in a timely manner is essential. Equally important, the selected candidate will be able to work effectively in a multidisciplinary team, will be proactive in the identification of tasks to support the project and will communicate the results in a clear and effective manner.

Main Tasks and Responsibilities

• Collaborate with multi-disciplinary teams in the discovery and development of small molecules with potency, selectivity, and in vitro/ in vivo stability using structure-guided approaches.

• Implement individual methods and integrated pipelines that will generate and process large libraries of virtual small molecules for virtual screening and evaluate smaller sets of the most promising compounds to prioritize downstream efforts.

• Analyze data from experimental and computational assays to improve methodology throughout the SEE-Tx discovery platform.

• Innovate SEE-Tx computational design platform by building state-of-the-art computational chemistry metrics and protocols.

Essential Requirements

The following specific computational chemistry skills are considered essential. The candidate should be proficient on most of them and will be able to master the rest in a short amount of time

• Molecular dynamics

• Molecular docking (protein-ligand)

• MD-based free energy calculations

• Advanced method for analysis of MD trajectories (e.g., MSM, clustering)

• Experience in the use of X-ray crystallographic or cryo-EM data

Knowledge on one or more of these specific areas is an important advantage:

• Chemoinformatics

• Machine learning

• Homology modelling

• Bioinformatics

As someone familiar in the use of computers, the candidate will have excellent command of shell scripting, python programming and the use of high-performance computing environments.

Knowledge of adjacent scientific areas, such as structural biology, medicinal chemistry, molecular biology, pharmacology, etcetera, will facilitate the integration in multidisciplinary teams and will be considered as a plus.

• Fluent in English

We Offer:

• Full time contract. Salary will be commensurate with academic level and experience.

• Stimulating, interdisciplinary research and high-quality scientific environment.

• Measures to reconcile work and family life.

How To Apply:

Interested applicants should send their CV, cover letter and the contact of two referees to: This email address is being protected from spambots. You need JavaScript enabled to view it.

This email address is being protected from spambots. You need JavaScript enabled to view it.

Offer Description

We are looking for an experienced, enthusiastic and committed cell biologist to join the Biology Team at Gain Therapeutics. This position requires a self-motivated and productive scientist who enjoys collaborating with other colleagues to conduct research and contribute to the development of treatments of diseases with high unmet medical needs.

Main Tasks and Responsibilities

• Run, develop, and troubleshoot cell-based and biochemical assays to screen and characterize small-molecule modulators using a wide range of technologies such as activity assays, flow cytometry or cellular imaging.

• Oversee assays and report data run by external CROs and monitor results for quality.

• Contribute to laboratory maintenance as part of the team

• Communicate progress and results in project meetings.

Essential Requirements

• Bachelor’s Degree in Life Sciences and Health with a minimum of 3 years post degree experience in an industry/academic lab setting.

• Experience using software systems to process and analyze assay data (e.g. Excel, GraphPad Prism)

• Skills in molecular and cell biology techniques.

• Strong organizational skills with excellent attention to detail. High flexibility. Can cope with change.

• Responds well to scientific challenge and applies significant rigor to their own work

• Fluent in English.

We Offer:

• Full time contract. Salary will be commensurate with academic level and experience.

• Stimulating, interdisciplinary research and high-quality scientific environment.

• Measures to reconcile work and family life.

How To Apply:

Interested applicants should send their CV, cover letter and the contact of two referees to: This email address is being protected from spambots. You need JavaScript enabled to view it.

This email address is being protected from spambots. You need JavaScript enabled to view it.